Description :

A number of cancers have been found to utilize the sonic hedgehog shh signaling pathway including some of the most prevalent in the world small cell lung carcinoma basal cell carcinoma medulloblastoma glioblastoma as well as breast liver colon pancreatic and prostate cancer have all been shown to use the shh pathway 1 . Mechanism of action of hedgehog pathway inhibitors given the role of shh signaling in promoting tumor progression and in the failure of anti cancer therapies the hedgehog signaling pathway is an important therapeutic target for restricting tumor progression and to prevent disease recurrence post treatment. Introduction sonic hedgehog shh a mammalian homologue of drosophila secreted morphogen hedgehog is crucial for the development of various embryonic tissues in invertebrate and vertebrate development including brain spinal cord axial skeleton limbs lungs gut and hematopoietic cells1 4shh is synthesized in epithelial cells its membrane receptor patched1 ptc1 is expressed in . Shh signaling pathway is a valid therapeutic goal in a broad range of cancers such as pancreas prostate breast and brain tumors we focus here on brain tumors